Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.

摘要: With their widespread application in industry, agriculture, medicine, and daily life, rare earth elements (REEs) are widely used various fields eventually accumulated human body. Therefore, understanding the effects of REEs on health has become more important. In this work, neurotoxicity lanthanum (La) was evaluated. Wistar rats were exposed to chloride through oral administration at 0, 0.1, 2, 40 mg/kg doses from gestation day 0 6 months age. Experiments carried out reveal La exposure brain functions four aspects including behavioral performance, [Ca2+](i) level activity Ca2+-ATPase (adenosine triphosphatase) hippocampal cells, oxidative stress, Nissl staining. Adverse observed 2 dose groups increased with dose. Morris water maze test showed that could significantly impair performance. (The preference for target quadrant decreased by 16.6% 19.4% versus control, respectively.) The neurotoxicological consequences demonstrated alteration homeostasis [Ca2+](i)/Ca2+-ATPase (the ratio vs. 44% group), inhibition activities antioxidant enzymes, subsequent cell damage (18% 23% loss CA3 subregion group, respectively) might be involved neurological adverse exposure.