In-practice evaluation of whole-blood Helicobacter pylori test: its usefulness in detecting peptic ulcer disease.

摘要: BACKGROUND: Approximately 10% of patients presenting with dyspepsia to the general practitioner have peptic ulcers; large majority which are related infection Helicobactor pylori. Office-based tests for H. pylori detection generally validated and evaluated in selected patient groups. AIM: To evaluate clinical effectiveness a whole-blood serology test Helicobacter detecting ulcer disease (PUD) daily practice. METHOD: A descriptive study 171 primary care open-access endoscopy aged between 18 75 years, 92 practices central, southern, eastern parts Netherlands. status was assessed using BM-test pylori, is identical Helisal test. Dyspepsia severity score measured symptom score. Symptom characteristics probability relevant were by practitioner. Endoscopy carried out local hospitals. Diagnostic outcome both reference supplied specialists. The against endoscopic results. RESULTS: high number (61.8%) false-negative BM-tests resulted low sensitivity (95% confidence interval [CI] = 48-75%) infection. Only 12 32 PUD had positive BM-test, resulting likelihood ratio (LR) 1.41 negative LR 0.85. CONCLUSIONS: This confirms relatively poor performance practice, shows limited diagnostic value office-tests care. discriminative result too small support either 9test-and-endoscope9 9test-and-treat9 strategy