La mitocondria y el corazón

摘要: The heart is highly dependent for its function on oxidative energy generated in mitochondria, primarily by fatty acid β-oxidation, respiratory electron chain and phosphorylation. Defects mitochondrial structure have been found association with cardiovascular diseases such as dilated hypertrophy cardiomyopathy, cardiac conduction defects sudden death, ischemic alcoholic well myocarditis. While a subset of these abnormalities defined genetic basis (e.g. DNA changes leading to phosphorylation dysfunction,fatty β-oxidation due specific nuclear mutations), other appear be more sporadic or environmental cardiotoxic insult not yet characterized. This review focuses bioenergetic associated diseases, their significance pathogenesis the available diagnostic therapeutic options. A concise background concerning biogenesis pathways during growth,development aging will also provided.