Applications of molecular techniques to fine-needle aspiration biopsy.

摘要: The effectiveness of fine-needle aspiration biopsy (FNAB) for rendering a specific diagnosis can be improved by applying several ancillary modalities. This review details applications molecular techniques using FNAB specimens with an emphasis on those used patient care. A detailed search the literature was conducted to collect all reports that different types tests. Several tests, including in-situ hybridization, polymerase chain reaction, Southern blotting, and gene microarrays have been reported. These tests organ systems objectives, detection cancer cells, diagnosis, distinction benign malignant disease, prediction response chemotherapy, risk assessment, selection patients targeted therapy. Except few such as assessment HER2/neu amplification in breast cancer, clonality hematopoietic neoplasms, chromosomal translocations former soft tissue sarcoma, most are currently investigational. reported indicates excellent potential material procured from almost any type test. Whereas these alone care, some them clinical use near future.