Studies on the laxative activity of triphenylmethane derivatives; relationship between structure and activity of phenolphthalein congeners.

摘要: 1 . By a study of the laxative potency in monkey 46 isomers, homologs and analogs phenolphthalein, some light is shed upon structural factors which vary laxophoric character basic two-ring skeleton govern modification cathartic activity by substituents. 2. In class isomers variation hydroxyl other substituents at free benzene rings, blocking groups, could be expressed series rules are compatible with certain concepts spatial arrangement intramolecular kinetics. Maximum series, 1.63 times that was embodied racemic trihydric pyrogallolbenzenephthalein, suggests possibility still higher an optical isomer. 3. skeletal system decreased those compounds studied part enlarged substitution, when phthalide replaced phthalimide, N-methylphthalimide or anthrone, but greatly increased it isatin, N-acetylisatin naphthalide. Phenolnaphthalein had 5 isatins up to 17 phenolphthalein. 4. Reasons presented for discarding older views concerning mechanism action phenolphthalein its congeners.