A method for evaluation of laxative habits in human subjects.

摘要: Abstract 1. A method is described for detecting laxative action in normal human subjects and measuring the potency of agents constipated patients. 2. Since record all observations on a daily report card, one physician can apply method, retaining most advantages “double-blind” test. Dosage constant over 1- or 2-week intervals. 3. Both frequency consistency stool are measured, correlation between these two responses only +0.5. The subjective categorical judgments converted to single numerical value by ridit transformation. 4. an unknown agent emerges from comparison its results with those placebo. sensitivity calibrated standard laxative, USP fluid extract cascara sagrada doses 2 c.c. 4 5. With this preparation, beverage containing bran, was not distinguished placebo group 40 nor 20 6. Dosage-response curves patients indicate that greatest dosage change lies below 0.5 Gm. powdered sagrada.