Estimation of grossly detectable isoproterenol-induced myocardiopathies in rats using the ridit transformation
作者： Hubert C. Stanton
DOI: 10.1016/0041-008X(66)90116-5
关键词:
摘要: Abstract This study illustrates an application of the ridit (Relative to Identified Distribution) transformation in analyzing subjective data form cardiac necrosis scores obtained from rats treated with large multiple doses isoproterenol. Animals isoproterenol (80 mg/kg, s.c.) administered twice daily for 2 days served as reference class, and values were calculated gross this group. A relationship between dose severity damage (expressed terms average values) was demonstrated. The interpretation after is discussed. Cardiac enlargement also observed a function dose, but maximal occurred which induced only minimal damage. Possible mechanisms responsible toxicity are
elsevier.com
sci-hub.se 参考文章(9)
Irwin D. J. Bross, How to Use Ridit Analysis Biometrics. ,vol. 14, pp. 18- 38 ,(1958) , 10.2307/2527727
J. WELDON BELLVILLE, IRWIN D. J. BROSS, WILLIAM S. HOWLAND, A method for the clinical evaluation of antiemetic agents. Anesthesiology. ,vol. 20, pp. 753- 760 ,(1959) , 10.1097/00000542-195911000-00002
Theodore Greiner, Irwin Bross, Harry Gold, A method for evaluation of laxative habits in human subjects. Journal of Chronic Diseases. ,vol. 6, pp. 244- 255 ,(1957) , 10.1016/0021-9681(57)90006-1
Ernest L. Wynder, Sven Hultberg, Folke Jacobsson, Irwin J. Bross, Environmental factors in cancer of the upper alimentary tract.A swedish study with special reference to plummer-vinson (Paterson-Kelly) syndrome Cancer. ,vol. 10, pp. 470- 487 ,(1957) , 10.1002/1097-0142(195705/06)10:3<470::AID-CNCR2820100309>3.0.CO;2-7
T Balazs, G Rona, R Gaudry, C I Chappel, An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. A.M.A. archives of pathology. ,vol. 67, pp. 443- 455 ,(1959)
J. R. Weeks, J. A. Jones, Routine direct measurement of arterial pressure in unanesthetized rats. Experimental Biology and Medicine. ,vol. 104, pp. 646- 648 ,(1960) , 10.3181/00379727-104-25937
J. T. Brock, M. Dyken, The anticonvulsant activity of chlordiazepoxide and Ro 5-2807 Neurology. ,vol. 13, pp. 59- 59 ,(1963) , 10.1212/WNL.13.1.59
C P Handforth, Isoproterenol-induced myocardial infarction in animals. Archives of pathology. ,vol. 73, pp. 161- 165 ,(1962)
Schwartz A, Stanton Hc, Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats. Proceedings of the Western Pharmacology Society. ,vol. 9, pp. 6- 8 ,(1966)