Inorganic arsenic exposure increased expression of Fas and Bax gene in vivo and vitro
作者： Yuefeng He , Ruobing Zhang , Xiaoxiao Song , Li Shang , Xinan Wu
DOI: 10.1016/J.GENE.2018.05.121
关键词: Toxicity 、 Gene expression 、 Regulator gene 、 Biology 、 Apoptosis 、 Molecular biology 、 Sodium arsenite 、 Arsenic 、 Fas receptor 、 In vivo 、 Genetics 、 General Medicine
摘要: Abstract Accumulating evidences have shown that apoptosis plays an important role in mediating the therapeutic effects and toxicity of arsenic. Fas Bax genes are critical regulatory for apoptosis. In this study, we investigated association between levels expression three arsenic species (inorganic (iAs), monomethylarsonic acid (MMA) dimethylarsinic (DMA)) vivo vitro. Three urine were measured examined by quantitative real-time PCR (qPCR) all subjects. We found mRNA exposed group significantly higher than control group. The gene positively correlated with concentrations urinary iAs, MMA DMA Sodium arsenite induced expression, then did not induce MDA-MB-231 XWLC-05 cells. findings present study indicated MMA, had different on gene.
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