Comparative Developmental Anatomy of the Murine and Human Definitive Placentae

摘要: The placenta of eutherian mammals is a remarkable biological structure. It composed both zygote-derived and maternal cells, mediates the complex interactions between mother fetus that are necessary for fetal growth survival. While genetic basis human placental development function largely unknown, its understanding immense clinical importance because placentopathies unknown aetiology thought to be cause many types pregnancy complications including unexplained miscarriage intrauterine retardation. mouse best-studied mammalian experimental model system research not restricted by inherent ethical practical limitations associated with human. As result, knowledge about control has expanded greatly in recent years. In order this benefit medical practice, extrapolations from murine placentation have made. However, comprehensive comparisons placentae these two species rare. This review therefore compares developmental anatomy humans mice emphasis on structures cell might analogous species. could particular geneticists who study an interest possible implications their work.