CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.
作者： S de Denus , J L Rouleau , D L Mann , G S Huggins , N L Pereira
DOI: 10.1038/TPJ.2017.8
关键词: Ejection fraction 、 Sildenafil 、 Medicine 、 Internal medicine 、 Population 、 Cardiology 、 Heart failure with preserved ejection fraction 、 Repeated measures design 、 Endocrinology 、 Randomized controlled trial 、 Heart failure 、 Pharmacogenetics
摘要: Despite its established inter-individual variability, sildenafil has been the subject of only a few pharmacogenetic investigations, with limited data regarding genetic modulators pharmacokinetics. We conducted sub-study patients randomized to (n=85) in RELAX trial, which investigated impact high-dose heart failure preserved left ventricular ejection fraction (HFpEF). In overall population, CYP3A4 inferred phenotype appeared associated dose-adjusted peak concentrations at week 12 and 24 (adjusted P=0.045 for repeated measures analysis), although this P-value did not meet our corrected significance threshold 0.0167. more homogeneous Caucasian subgroup, association was significant P=0.0165 measures). Hence, is HFpEF receiving high doses sildenafil. The clinical requires further investigation.
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