The palladium catalyzed allylic alkylation of bis(trimethylsilyl) substituted propenyl acetates or carbonates in the presence of chiral ligands
作者： Donna L. Romero , Edward L. Fritzen
DOI: 10.1016/S0040-4039(97)10380-X
关键词: Palladium 、 Ligand 、 Medicinal chemistry 、 Catalysis 、 Allylic rearrangement 、 Organic chemistry 、 Chemistry 、 Trimethylsilyl 、 Oxazoline 、 Propenyl 、 Tsuji–Trost reaction
摘要: Abstract Palladium catalyzed asymmetric allylic alkylations of a bis(trimethylsilyl) substituted propenyl acetate and carbonate were investigated using various chiral ligands reaction conditions. The best enantioselectivity (86% e.e.) was obtained with the substrate 1-phenyl-3,3-bis(trimethylsilyl)propenyl 13 oxazoline ligand 4c .
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