Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions
作者： Michael J Goard , Gerald N Pho , Jonathan Woodson , Mriganka Sur
DOI: 10.7554/ELIFE.13764
关键词: Sensory system 、 Brain mapping 、 Visual perception 、 Visual cortex 、 Psychology 、 Stimulus (physiology) 、 Population 、 Short-term memory 、 Neuroscience 、 Parietal lobe
摘要: Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role visual (V1), posterior parietal (PPC), and frontal (fMC) cortices for sensorimotor mapping in mice during performance memory-guided discrimination task. Large-scale calcium imaging revealed that V1, PPC, fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding stimulus identity behavioral choice information across regions, with V1 stimulus, even early trial, PPC multiplexing two variables. Optogenetic inhibition behavior regions were necessary epoch, but only was required delay response epochs. Stimulus can thus be rapidly transformed into choice, requiring transformation period, maintaining memory prior execution.
elifesciences.org
sci-hub.se 参考文章(81)
Kartik K. Sreenivasan, Clayton E. Curtis, Mark D’Esposito, Revisiting the role of persistent neural activity during working memory Trends in Cognitive Sciences. ,vol. 18, pp. 82- 89 ,(2014) , 10.1016/J.TICS.2013.12.001
Ding Liu, Xiaowei Gu, Jia Zhu, Xiaoxing Zhang, Zhe Han, Wenjun Yan, Qi Cheng, Jiang Hao, Hongmei Fan, Ruiqing Hou, Zhaoqin Chen, Yulei Chen, Chengyu T. Li, Medial prefrontal activity during delay period contributes to learning of a working memory task Science. ,vol. 346, pp. 458- 463 ,(2014) , 10.1126/SCIENCE.1256573
Ranulfo Romo, Victor de Lafuente, Conversion of sensory signals into perceptual decisions Progress in Neurobiology. ,vol. 103, pp. 41- 75 ,(2013) , 10.1016/J.PNEUROBIO.2012.03.007
Daniel H O'Connor, Nathan G Clack, Daniel Huber, Takaki Komiyama, Eugene W Myers, Karel Svoboda, None, Vibrissa-Based Object Localization in Head-Fixed Mice The Journal of Neuroscience. ,vol. 30, pp. 1947- 1967 ,(2010) , 10.1523/JNEUROSCI.3762-09.2010
Matteo Carandini, Anne K Churchland, Probing perceptual decisions in rodents. Nature Neuroscience. ,vol. 16, pp. 824- 831 ,(2013) , 10.1038/NN.3410
Takaki Komiyama, Takashi R. Sato, Daniel H. O’Connor, Ying-Xin Zhang, Daniel Huber, Bryan M. Hooks, Mariano Gabitto, Karel Svoboda, Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice. Nature. ,vol. 464, pp. 1182- 1186 ,(2010) , 10.1038/NATURE08897
Shozo Kojima, Patricia S. Goldman-Rakic, Delay-related activity of prefrontal neurons in rhesus monkeys performing delayed response Brain Research. ,vol. 248, pp. 43- 50 ,(1982) , 10.1016/0006-8993(82)91145-3
B. L. McNaughton, S. J. Y. Mizumori, C. A. Barnes, B. J. Leonard, M. Marquis, E. J. Green, Cortical Representation of Motion during Unrestrained Spatial Navigation in the Rat Cerebral Cortex. ,vol. 4, pp. 27- 39 ,(1994) , 10.1093/CERCOR/4.1.27
Simon P. Peron, Jeremy Freeman, Vijay Iyer, Caiying Guo, Karel Svoboda, A Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior Neuron. ,vol. 86, pp. 783- 799 ,(2015) , 10.1016/J.NEURON.2015.03.027
Björn M Kampa, Morgane M Roth, Werner Göbel, Fritjof Helmchen, Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex. Frontiers in Neural Circuits. ,vol. 5, pp. 18- 18 ,(2011) , 10.3389/FNCIR.2011.00018