Vibrissa-Based Object Localization in Head-Fixed Mice

摘要: Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments genetic model systems such as the mouse. In head-fixed primates, combination of precise stimulus control, monitoring motor output, physiological recordings over large numbers trials are foundation on which many conceptually rich studies have been built. Choice-based, paradigms for mice not described previously. Here, we report a somatosensory absolute object localization task mice. Mice actively used their mystacial vibrissae (whiskers) to sense location vertical pole presented one side head reported licking whether was target (go) or distracter (no-go) location. performed hundreds high performance (>90% correct) localized