Invasive Fungal Infections in the Child with Chronic Granulomatous Disease

摘要: Invasive fungal infections (IFI) are a major threat for patients with chronic granulomatous disease (CGD) which is an inherited disorder of NADPH oxidase. The absence functional oxidase complex affects the display efficient antimicrobial effect as well controlled inflammatory response. aspergillosis caused by either Aspergillus fumigatus or A. nidulans most common IFI. seem to unique interaction CGD host and seldom reported in other immunocompromised hosts. occurrence mucormycosis mainly noted setting treatment complications immunosuppressive drugs. Candida infrequently seen show age-dependent clinical presentation affecting infants young children. Furthermore, child susceptible wide range pathogens, indicating need determine causative fungus, often invasive diagnostic approaches, guide optimal rational treatment. Currently, it becoming more clear that exaggerated response infection leading pathogenesis, antiinflammatory might become important antifungal this specific host.