Ice cleaved alpha-synuclein a biomarker

作者: Dagmar Ringe , Gregory A. Petsko

DOI:

关键词: Biomarker (medicine)Biomarker discoveryAlpha-synucleinCancer researchMedicine

摘要: The present disclosure provides ICE-cleaved alpha-synuclein fragments as biomarkers for alpha-synuclein-associated disease or disorder and/or ICE-regulator therapy.

参考文章(190)
Hamish Allen, William Harter, Bruce Roth, Hans Albrecht, Catherine Kostlan, Kenneth Brady, Nigel Walker, Sulfonamide interleukin-1beta converting enzyme inhibitors ,(2001)
Paul Galatsis, Joseph Scott Warmus, Robert Vincent Talanian, Hamish John Allen, John Lodge Gilmore, Kenneth Dale Brady, Bradley William Caprathe, Nigel Walker, Sheryl Jeanne Hays, Hydroxamate inhibitors of interleukin-1β converting enzyme ,(1997)
Perttu Permi, Paul R. Rosevear, Arto Annila, A set of HNCO-based experiments for measurement of residual dipolar couplings in 15N, 13C, (2H)-labeled proteins. Journal of Biomolecular NMR. ,vol. 17, pp. 43- 54 ,(2000) , 10.1023/A:1008372624615
Demetrius Maraganore, Timothy Lesnick, Dennis Ballinger, David Cox, Krishna Pant, Parkinson's disease-related disease compositions and methods ,(2006)
Guilio Pasinetti, Biomarker for Parkinson's disease ,(2004)
Elvin A. Kabat, Sequences of proteins of immunological interest National Institutes of Health. ,(1991)
Mark S. Williams, Matthew L. Charles, Tissue kallikrein for the treatment of parkinson's disease ,(2009)
Dennis J. Selkoe, Tim Bartels, Dagmar Ringe, Gregory A. Petsko, Tetrameric alpha-synuclein as biomarkers ,(2011)
Deborah E. Cabin, Kazuhiro Shimazu, Diane Murphy, Nelson B. Cole, Wolfram Gottschalk, Kellie L. McIlwain, Bonnie Orrison, Amy Chen, Christopher E. Ellis, Richard Paylor, Bai Lu, Robert L. Nussbaum, Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein The Journal of Neuroscience. ,vol. 22, pp. 8797- 8807 ,(2002) , 10.1523/JNEUROSCI.22-20-08797.2002
Joseph S. Wall, Martha N. Simon, Beth Y. Lin, Serge N. Vinogradov, Mass mapping of large globin complexes by scanning transmission electron microscopy. Methods in Enzymology. ,vol. 436, pp. 487- 501 ,(2008) , 10.1016/S0076-6879(08)36027-3