Anti-AIDS Agents. 46.1 Anti-HIV Activity of Harman, an Anti-HIV Principle from Symplocos setchuensis, and Its Derivatives
作者： Junko Ishida , Hui-Kang Wang , Masayoshi Oyama , Mark L. Cosentino , Chang-Qi Hu
DOI: 10.1021/NP0101189
关键词: Matairesinol 、 Acquired immunodeficiency syndrome (AIDS) 、 Therapeutic index 、 Biochemistry 、 Pharmacology 、 Lentivirus 、 Lymphocyte 、 Viral replication 、 Chemistry 、 In vitro 、 Virus
摘要: Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives 5 revealed that compound 19 showed potent activity with EC50 therapeutic index values 0.037 μM 210, respectively.
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