Elucidating the Role of Biliverdin Reductase in the Expression of Heme Oxygenase-1 as a Cytoprotective Response to Stress

摘要: Many types of enzymes in living systems use hemin as a prosthetic group to catalyze oxidation/reduction reactions or for the binding/transport reactive molecules (e.g. oxygen). For instance, several cytochromes mitochondrial electron transport chain are “heme” major drug/xenobiotic-metabolizing endoplasmic reticulum, P450 (CYP P450). The heme P450s allows these redox chemistry bind molecular oxygen and cleave O-O bond, thus forming reactive, high-valent species that can insert into otherwise stable carbon-hydrogen bonds drugs/xenobiotics (White Coon, 1980). unfavorable thermodynamics this type reaction has caused be likened “catalytic blowtorches” (Schlichting et al., 2000), process is essential elimination clearance many lipophilic compounds ingested from environment. Catalase an important protective enzyme responsible degrading N