FAST and SLOW amygdala kindling rat strains: comparison of amygdala, hippocampal, piriform and perirhinal cortex kindling

摘要: Abstract In our companion paper, we selectively bred offspring of a Long Evans Hooded and Wistar rat cross for either fast or slow rates amygdala kindling (Racine et al., 1999. Development kindling-prone resistant rats: Selective breeding electrophysiological studies, Epilepsy Res. 35, 183–195). Within 10 generations, there was no overlap in the distribution between these newly developed FAST SLOW strains. present report, compared local excitability, rates, convulsion profiles sites amygdala, dorsal hippocampus, piriform cortex perirhinal two Local measured as afterdischarge (AD) threshold its duration, showed varied effects structures Before kindling, AD lower than rats cortices, but not (the selection structure). Also, duration significantly longer all structures, except CA 1 hippocampus. Most differences were maintained after kindling. Kindling itself faster with structures; however, different structural proportional strains that about five times only This suggested bias networks. As other strains, fastest seen followed by cortex, hippocampus both rats. Other important occurred stage-5 profiles, including latency to forelimb clonus, clonus associated afterdischarges. The discussed respect possible underlying mechanisms, significance epileptogenesis, impact on normal behaviours.