Revisiting the pathologic finding of diffuse alveolar damage after lung transplantation

摘要: Background Diffuse alveolar damage (DAD) is a non-specific pathologic diagnosis frequently encountered after lung transplantation. We examined the relationship between DAD and different forms of chronic allograft dysfunction (CLAD). Methods reviewed results 4,085 transbronchial biopsies obtained from 720 transplant recipients. detected in within 3 months newly were defined as early late new-onset DAD, respectively. Among patients with CLAD (FEV 1 Results was observed 320 (44.4%) at least once; 264 707 (37.3%) 87 655 (13.3%) patients, Early associated significantly higher 90-day mortality (20 [7.6%] vs 11 443 [2.5%]; p = 0.001). Moreover, among 502 bilateral recipients who had sufficient pulmonary function tests to distinguish BOS RAS, earlier onset (hazard ratio [HR] 1.24; confidence interval [CI] 1.04 1.47; 0.017; median time onset: 2,902 4,005 days). Conversely, treated time-varying covariate, significant risk factor for RAS Cox model (HR 36.8; CI 18.3 74.1; Conclusions BOS, increases RAS.