Outcome of lung transplanted patients with primary graft dysfunction.

摘要: Objective: Primary graft dysfunction (PGD) causes significant mortality and morbidity after lung transplantation. The objectives of the study were to describe theclinicaland histological sequelaeof PGD.Methods:Histologyofall patientsreceivingsingle-lungtransplantation 1999—2004 (n = 181) was reviewed. PGD defined as diffuse radiological infiltration allograft occurring within first 72 h postoperatively. Results: One patient died intra-operatively. recorded in 63% 113) 180 consecutive transplant recipients. Patients with had a worse 90-day postoperative (14% versus 3%, p 0.03) 3-year survival (55% 77%, 0.003). Freedom from bronchiolitis obliterans syndrome similar both groups. maximal FEV1 significantly lower patients PGD, median 54% (quartiles 48—61%) predicted; compared without 59% 54—69%) predicted (p There linear trend declineofmaximalFEV1withthepresenceandincreasingseverityofradiographicinfiltrate(p 0.004).Duringfollow-up,patientswithPGDwere more likely demonstrate alveolar damage or organizing pneumonia 0.009 0.01, respectively). Histological findings correlated closely extent < 0.0001). Conclusions: Transplant recipient survival, function, appear be appearance severity PGD. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.