Cognitive Function in Children with Lupus Nephritis: A Cross-Sectional Comparison with Children with Other Glomerular Chronic Kidney Diseases
作者： Andrea Knight , Amy J. Kogon , Matthew B. Matheson , Bradley A. Warady , Susan L. Furth
DOI: 10.1016/J.JPEDS.2017.06.044
关键词: Prednisone 、 Neurocognitive 、 Systemic lupus erythematosus 、 Kidney disease 、 Medicine 、 Lupus nephritis 、 Pediatrics 、 Propensity score matching 、 Logistic regression 、 Physical therapy 、 Quality of life
摘要: Objective To identify factors contributing to cognitive impairment in children with lupus nephritis. Study design A cross-sectional analysis of a large multicenter national cohort chronic kidney disease (CKD) using standardized measures determine baseline neuropsychiatric function and health-related quality life (HRQoL) nephritis (n = 34), compare that other forms glomerular CKD (gCKD; n = 171). We used inverse probability weighting via logistic model for propensity score achieve balance between those causes CKD, adjusting known confounders. linear regression models neurocognitive outcomes exposure groups, current prednisone use testing an interaction nephritis, test association HRQoL. Results Current was independently associated worse attention (P Conclusion Children have comparable or better than their peers gCKDs, which is reassuring given the multiorgan lifelong complications lupus.
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