A linear free energy analysis of PAMPA models for biological systems
作者： Jia He , Michael H. Abraham , William E. Acree , Yuan H. Zhao
DOI: 10.1016/J.IJPHARM.2015.10.064
关键词: Free-energy relationship 、 Synthetic membrane 、 Egg lecithin 、 Linear model 、 Membrane 、 Principal component analysis 、 Chemistry 、 Permeation 、 Chromatography 、 Energy analysis 、 Biological system
摘要: Equation coefficients in the Abraham linear free energy relationship have been obtained for a number of parallel artificial membrane permeability assays, PAMPA, and compared to equation several biological processes large water-solvent partitions. From principal component analysis we show that one particular PAMPA (Wohnsland Faller, 2001) is good model human intestinal absorption, but could find no was rat brain permeation, mouse blood-brain distribution, skin permeation or water-skin partition, although models include other descriptors may be useful. The water-octanol system poor all process studied, water-nonpolar solvent partitions are through egg lecithin membranes.
sci-hub.se 参考文章(27)
Oksana Tsinman, Alex Avdeef, PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models. European Journal of Pharmaceutical Sciences. ,vol. 28, pp. 43- 50 ,(2004) , 10.1016/J.EJPS.2005.12.008
Michael H. Abraham, Joelle M.R. Gola, Adam Ibrahim, William E. Acree, Xiangli Liu, A simple method for estimating in vitro air-tissue and in vivo blood-tissue partition coefficients Chemosphere. ,vol. 120, pp. 188- 191 ,(2015) , 10.1016/J.CHEMOSPHERE.2014.06.037
Michael H. Abraham, The Permeation of Neutral Molecules, Ions, and Ionic Species Through Membranes: Brain Permeation as an Example Journal of Pharmaceutical Sciences. ,vol. 100, pp. 1690- 1701 ,(2011) , 10.1002/JPS.22404
Michael H. Abraham, Adam Ibrahim, Yuan Zhao, William E. Acree, A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data Journal of Pharmaceutical Sciences. ,vol. 95, pp. 2091- 2100 ,(2006) , 10.1002/JPS.20595
Filomena Martins, Michael H. Abraham, Human Skin Permeation and Partition: General Linear Free‐Energy Relationship Analyses Journal of Pharmaceutical Sciences. ,vol. 93, pp. 1508- 1523 ,(2004) , 10.1002/JPS.20070
Elizabeth E. Hills, Michael H. Abraham, Anne Hersey, Chris D. Bevan, Diffusion coefficients in ethanol and in water at 298 K: Linear free energy relationships Fluid Phase Equilibria. ,vol. 303, pp. 45- 55 ,(2011) , 10.1016/J.FLUID.2011.01.002
Claude Dagenais, Alex Avdeef, Oksana Tsinman, Adam Dudley, Richard Beliveau, P-Glycoprotein Deficient Mouse in situ Blood-Brain Barrier Permeability and its Prediction using an in combo PAMPA Model European Journal of Pharmaceutical Sciences. ,vol. 38, pp. 121- 137 ,(2009) , 10.1016/J.EJPS.2009.06.009
H. Lennernäs, Intestinal permeability and its relevance for absorption and elimination. Xenobiotica. ,vol. 37, pp. 1015- 1051 ,(2007) , 10.1080/00498250701704819
Jeffrey Alan Ruell, Oksana Tsinman, Alex Avdeef, Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. Chemical & Pharmaceutical Bulletin. ,vol. 52, pp. 561- 565 ,(2004) , 10.1248/CPB.52.561
Johanna Linnankoski, Johanna M Mäkelä, Veli-Pekka Ranta, Arto Urtti, Marjo Yliperttula, Computational prediction of oral drug absorption based on absorption rate constants in humans. Journal of Medicinal Chemistry. ,vol. 49, pp. 3674- 3681 ,(2006) , 10.1021/JM051231P