The Permeation of Neutral Molecules, Ions, and Ionic Species Through Membranes: Brain Permeation as an Example
作者： Michael H. Abraham
DOI: 10.1002/JPS.22404
关键词:
摘要: ABSTRACT Known descriptors for ions and ionic species (deprotonated carboxylic acid anions protonated base cations) can be combined with neutral to obtain a general equation permeation from saline through the blood–brain barrier. The used indicate compound factors that influence show how substituent effects on compounds may altered increase or decrease rate of permeation. It is shown log PS values carboxylate are about 2.0 units less than those acids, cations 1.0 bases. possible use obtained calculate an either totally ionized partly in perfusate. same method analyze water–artificial membrane partition coefficients set include species.
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