Measurement of Tumor Proliferation with Positron Emission Tomography and Treatment Response

摘要: While the ultimate goal of cancer treatment is to eliminate all evidence tumor’s presence, more immediate with chemotherapy, radiation, and biological agents decrease ability replicate increase death rate cells. This basis has inspired researchers design develop imaging approaches assess tumor proliferation and, importantly, a response new treatments. Such approaches, while still in development, may complement routine size now done as part standard clinical care. In general, successful therapy should lead declines tumors reflected by techniques such computed tomography (CT) magnetic resonance (MRI) (1,2). anatomic relatively straightforward readily available, it number limitation. First, measures mass, but does not determine cellularity or growth tumor. Second, after treatment, be left fibrotic mass that can persist even treatment. eventually decline therapy, this take many weeks months for cells lyse finally absorbed. Finally, when unsuccessful, failure become apparent, since grow very slowly. fact, doubling time most generally from 1 3 (3). It these reasons cell attractive potential use steer change course therapy. approach positron emission (PET) also other aspects metabolism, energetics, protein membrane synthesis, apoptosis.