Potential impact of [18F]3'-deoxy-3'-fluorothymidine versus [18F]fluoro-2-deoxy-D-glucose in positron emission tomography for colorectal cancer

摘要: Fluorine-18 labelled fluoro-2-deoxy-d-glucose (18FDG) positron emission tomography (PET) imaging demonstrates the increased glucose consumption of malignant cells, but problems with specificity have led to development new PET tracers. [18F]3'-deoxy-3'-fluorothymidine (18FLT) is a tracer which images cellular proliferation by entering salvage pathway DNA synthesis. In this study we compared uptake 18FLT and 18FDG in patients colorectal cancer (CRC). Seventeen 50 primary or metastatic CRC lesions were prospectively recruited. Lesions initially identified using computed tomography. Patients underwent both scanning. Semi-quantitative analysis was carried out standardised values. All tumours (n=6) visualised tracers, showing on average twice 18FLT. Similar tracers seen lung peritoneal lesions, five six all lesions. Of 32 liver metastases, 11 (34%) as avid for 18FLT, 31 (97%) 18FDG. No correlation between two (R2=0.03). shows high sensitivity detection extrahepatic disease poor making it unlikely role diagnostic CRC. We demonstrated that image distinct processes. The prognostic implications need be assessed terms response chemoradiotherapy survival.