Neuroprotective effects of SOX5 against ischemic stroke by regulating VEGF/PI3K/AKT pathway.
作者： Wu Zhang , Yuqin Wu , Hong Chen , Dan Yu , Jinfeng Zhao
DOI: 10.1016/J.GENE.2020.145148
关键词: Cancer research 、 Biology 、 PI3K/AKT/mTOR pathway 、 Nerve injury 、 Western blot 、 TUNEL assay 、 Viability assay 、 Neuroprotection 、 Apoptosis 、 Central nervous system
摘要: … by ischemic stroke. In conclusion, SOX5 transcription regulates the expression of VEGF to activate the PI3K/AKT pathway, which repaired nerve damage caused by ischemic stroke. …
sci-hub.st 参考文章(51)
Yi Zeng, Le Zhang, Zhiping Hu, Cerebral insulin, insulin signaling pathway, and brain angiogenesis Neurological Sciences. ,vol. 37, pp. 9- 16 ,(2016) , 10.1007/S10072-015-2386-8
Peter S Yoo, Abby L Mulkeen, Charles H Cha, Post-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis World Journal of Gastroenterology. ,vol. 12, pp. 4937- 4942 ,(2006) , 10.3748/WJG.V12.I31.4937
Guo-Xiang Ruan, Andrius Kazlauskas, Axl is essential for VEGF-A-dependent activation of PI3K/Akt The EMBO Journal. ,vol. 31, pp. 1692- 1703 ,(2012) , 10.1038/EMBOJ.2012.21
Linkun Chen, Shuguang Luo, Lingwan Yan, Weijia Zhao, A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack Journal of the Neurological Sciences. ,vol. 337, pp. 3- 7 ,(2014) , 10.1016/J.JNS.2013.11.027
D. Fukumura, T. Gohongi, A. Kadambi, Y. Izumi, J. Ang, C.-O. Yun, D. G. Buerk, P. L. Huang, R. K. Jain, Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 2604- 2609 ,(2001) , 10.1073/PNAS.041359198
S. Alex Marshall, Justin A. McClain, Matthew L. Kelso, Deann M. Hopkins, James R. Pauly, Kimberly Nixon, Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype. Neurobiology of Disease. ,vol. 54, pp. 239- 251 ,(2013) , 10.1016/J.NBD.2012.12.016
Eiman Azim, Denis Jabaudon, Ryann M Fame, Jeffrey D Macklis, None, SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development Nature Neuroscience. ,vol. 12, pp. 1238- 1247 ,(2009) , 10.1038/NN.2387
Kenneth Y Kwan, Mandy MS Lam, Željka Krsnik, Yuka Imamura Kawasawa, Veronique Lefebvre, Nenad Šestan, SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 16021- 16026 ,(2008) , 10.1073/PNAS.0806791105
Y. Kamachi, H. Kondoh, Sox proteins: regulators of cell fate specification and differentiation Development. ,vol. 140, pp. 4129- 4144 ,(2013) , 10.1242/DEV.091793
An-Ding Xu, Yong-Jun Wang, David Z Wang, , Consensus statement on the use of intravenous recombinant tissue plasminogen activator to treat acute ischemic stroke by the Chinese Stroke Therapy Expert Panel. CNS Neuroscience & Therapeutics. ,vol. 19, pp. 543- 548 ,(2013) , 10.1111/CNS.12126