The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons

作者: Marlena Zyśk , Monika Sakowicz-Burkiewicz , Piotr Pikul , Robert Kowalski , Anna Michno

DOI: 10.3390/ANTIOX9060522

关键词: Acetyl-CoAInternal medicineChemistryAcetylcholineHomeostasisEndocrinologyCholinergic neuronOxidative stressElectron transport chainCitric acid cycleTheophylline

摘要: N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the …

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