Renal vasculature reactivity to agonist of P2X7 receptor is increased in streptozotocin-induced diabetes
作者： Ewelina Kreft , Robert Kowalski , Maciej Jankowski , Mirosława Szczepańska-Konkel
DOI: 10.1016/J.PHAREP.2015.06.140
关键词: Endocrinology 、 Renal function 、 Nephropathy 、 Agonist 、 Adenosine 、 Purinergic receptor 、 Adenine nucleotide 、 Chemistry 、 Kidney 、 Internal medicine 、 Diabetic nephropathy 、 Pharmacology 、 General Medicine
摘要: Abstract Background Diabetic nephropathy is characterized by the dysfunction of renal microvasculature. The involvement P2X7 receptor, being a part purinergic system, presumable in this process. aim our study was to investigate receptor-mediated microvasculature response and metabolism extracellular adenine nucleotides diabetic rats. Methods Study performed on streptozotocin-induced Wistar vascular BzATP, an agonist monitored based changes cortical blood flow (CBF), glomerular filtration rate (GFR) inulin space (GIS). interstitial fluid (RIF) probed microdialysis technique concentrations ATP adenosine were measured. Activity NTDPase 5′-nucleotidases measured membranes. Results kidneys decreased RIF increased with accompanied enhancement 5′-nucleotidase activities. BzATP induced more pronounced increase CBF decrease GFR GIS diabetes These effects abolished A438079, antagonist receptor. Conclusions It possible that receptor reactivity may be involved pathogenesis nephropathy.
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