Circulating tumour cells—monitoring treatment response in prostate cancer
作者： David T. Miyamoto , Lecia V. Sequist , Richard J. Lee
DOI: 10.1038/NRCLINONC.2014.82
关键词: Molecular analysis 、 Oncology 、 Internal medicine 、 Treatment outcome 、 Response to therapy 、 Treatment response 、 Prostate cancer 、 In patient 、 Medicine
摘要: The availability of new therapeutic options for the treatment metastatic castration-resistant prostate cancer (mCRPC) has heightened importance monitoring and assessing response. Accordingly, there is an unmet clinical need reliable biomarkers that can be used to guide therapy. Circulating tumour cells (CTCs) are rare shed from primary deposits into peripheral circulation, represent a means performing noninvasive sampling. Indeed, enumeration CTCs before after therapy shown CTC burden correlates with prognosis in patients mCRPC. Moreover, studies have demonstrated potential molecular analysis predicting response patients. This Review describes challenges associated mCRPC, advancements CTC-analysis technologies applied such assessments and, ultimately, guiding treatment.
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