Localization of gastroentero-pancreatic (GEP) tumors

作者: A.I. Vinik , J. Glowniak , B. Glaser , B. Shapiro , A. Funakoshi

DOI: 10.1016/B978-0-407-02317-8.50011-2

关键词: GastrinHyperplasiaSomatostatinMedicineThyroidLymph nodeCarcinoid syndromeNesidioblastosisPathologyPancreas

摘要: Publisher Summary This chapter discusses the localization of gastroentero-pancreatic (GEP) tumors. Tumors axis occur predominantly in pancreas, and rarely duodenum stomach. Occasionally tumors secreting GEP hormones may even be found ectopic sites, that is, kidney, ovary, thyroid (G cell), lung (bronchial carcinoid) or adrenal medulla, they apparently confined to a solitary lymph node. The experience 11 patients with organic hyperinsulinism, 7 hypergastrinema, 1 carcinoid syndrome whom percutaneous transhepatic portal pancreatic vein catheterization was carried out successfully. helped localize tumors, identify multiple establish diagnosis nesidioblastosis hyperplasia, hormone secretion by same tumor within pancreas. also venous sampling (THVS) is safe reliable procedure has become an important experiment evaluation angiographically negative functioning islet cell lesions. It believed method will play fairly major role adenomas normal angiographic studies previously surgical explorations. As no clinical study managed distinguish from those single hyperplasia nesidioblastosis, THVS choice. Portal concentrations number have been measured, including gastrin, glucagon, motilin, somatostatin, insulin, which prove useful further designed axis.

参考文章(56)
M.N Rossor, Neurotransmitters and CNS disease. Dementia. The Lancet. ,vol. 2, pp. 1200- ,(1982) , 10.1016/S0140-6736(82)91212-0
JOHN C. FLOYD, STEFAN S. FAJANS, SUMER PEK, RONALD E. CHANCE, A newly recognized pancreatic polypeptide; plasma levels in health and disease. Recent Progress in Hormone Research. ,vol. 33, pp. 519- 570 ,(1977) , 10.1016/B978-0-12-571133-3.50019-2
J Fahrenkrug, K Oberg, L Grimelius, G Lundqvist, H Boström, L Lööf, Hypersecretion of calcitonin in patients with the Verner-Morrison syndrome. Scandinavian Journal of Gastroenterology. ,vol. 16, pp. 135- 144 ,(1981)
Patrassi N, Basoli A, Stefanini P, Carboni M, Beta-islet cell tumors of the pancreas: results of a study on 1,067 cases. Surgery. ,vol. 75, pp. 597- 609 ,(1974)
F. Stadil, L. Grimelius, L. Angervall, J. Holst, J. F. Rehfeld, R. Håkanson, F. Sundler, L. I. Larsson, Mixed endocrine pancreatic tumors producing several peptide hormones. American Journal of Pathology. ,vol. 79, pp. 271- 284 ,(1975)
L.-I. Larsson, J.J. Holst, C. Kühl, G. Lundqvist, M.A. Hirsch, S. Ingemansson, S. Lindkaer Jensen, J.F. Rehfeld, T.W. Schwartz, PANCREATIC SOMATOSTATINOMA: Clinical Features and Physiological Implications The Lancet. ,vol. 309, pp. 666- 668 ,(1977) , 10.1016/S0140-6736(77)92113-4
Flemming Burcharth, Jens G. Stage, Flemming Stadil, Lise Ingemann Jensen, Kaj Fischermann, Localization of gastrinomas by transhepatic portal catheterization and gastrin assay. Gastroenterology. ,vol. 77, pp. 444- 450 ,(1979) , 10.1016/0016-5085(79)90003-9
Sundler F, Fahrenkrug J, Schwartz T, Grimelius L, Larsson Li, Moon N, Lundqvist G, Chance Re, Schaffalitzky de Muckadell O, Rehfeld Jf, Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors. Possible implication in the watery diarrhea syndrome. American Journal of Pathology. ,vol. 85, pp. 675- 684 ,(1976)
R. K. Gray, J. Rösch, J. H. Grollman, Arteriography in the diagnosis of islet-cell tumors. Radiology. ,vol. 97, pp. 39- 44 ,(1970) , 10.1148/97.1.39
Jon M. Robins, Joseph J. Bookstein, Harold A. Oberman, Stefan S. Fajans, Selective Angiography in Localizing Islet-Cell Tumors of the Pancreas Radiology. ,vol. 106, pp. 525- 528 ,(1973) , 10.1148/106.3.525