The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
作者： Patricia A. Labosky , Klaus H. Kaestner , Nathalie Perreault , Bree G. Goldstein , Jonathan P. Katz
关键词: Cell division 、 Zinc finger transcription factor 、 Goblet cell 、 KLF4 、 Epithelial cell differentiation 、 Cellular differentiation 、 Molecular biology 、 Biology 、 Immunology 、 Epithelium 、 Gastrointestinal tract
摘要: … In this study, we provide the first in vivo evidence that Klf4 is a goblet cell-specific … All other epithelial cell types are present in the colon of Klf4 –/– mice. In summary, Klf4 plays a crucial …
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