Event-related potential correlates of selective processing in early- and continuously-treated children with phenylketonuria: Effects of concurrent phenylalanine level and dietary control

摘要: This study focused on important characteristics of attentional (selective) processing in children with early-treated phenylketonuria (PKU). Seven to 14-year-old PKU were allocated high phenylalanine (Phe) and low Phe groups compared control amplitudes latencies early late event-related potential (ERP) components elicited during a selective task. These are thought measure sensory processes (stimulus encoding/perception) later selection (target detection). The effects concurrent level dietary brain activity behavioural performance studied. Results showed that levels less accurate made more false alarms than controls levels. Both displayed the expected fronto-central negativity positive peak over posterior sites associated aspects attention However, contrast controls, an absence condition differences for positivity anterior target detection. Negative potentials dependent historical levels, whereas depended strongly It is concluded both affected by relative predictive strength suggests sensitive periods maturation may have long-lasting influences attention.