myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer.

摘要: The myc family DNA copy number of 291 specimens (183 tumors and 108 tumor cell lines) from patients with small-cell lung cancer has been reported in 15 different studies. Thirty-five (32%) lines have amplification (16 c-myc, 7 N-myc, 12 L-myc). Thirty-seven 183 (20%) (3 13 18 is similar the majority sites same patient. presence line also typically present a minority cancer, data on its association shorter survival are meager at present. Future studies biology may require use newer technologies that can work small tissue samples available start therapy.