홍삼산성다당체 (RGAP)와 항암제의 병용투여에 의한 항암시너지 효과
作者：
DOI: 10.5142/JGR.2003.27.2.047
关键词: Combined treatment 、 Adjuvant 、 Ginseng 、 Pharmacology 、 Life span 、 Cyclophosphamide 、 Survival rate 、 Medicine
摘要: Synergistic anticancer activities of red ginseng acidic polysaccharide (RGAP) showing immunomodulatory activity were evaluated by combined treatment with agents such as Cyclophosphamide (CY) or 5-Fluorouracil (5-FU) in experimental tumor models. The RGAP (100 mg/kg) and CY (3 exhibited 71% survival rate life span sarcoma 180-bearing mice, while single 10 43, 14 43% rates, respectively. In addition, when was administered in combination 5-FU (2.5 to 180 tumor-bearing higher found compared alone. Moreover, weights LL/2 lung carcinoma-bearing mice treated (5 10mg/kg) obviously decreased These results suggest that clinical trials an adjuvant cancer chemotheraphy can be higly feasible.
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