NK recognition of target structures: is the transferrin receptor the NK target structure?

摘要: That the transferrin receptor acts as a target antigen for human NK cells has previously been suggested. In this study we used two models to examine hypothesis that is recognized by cells. first model, employed mouse cloned in conjunction with species-specific monoclonal antibody R17 217, which binds murine receptor. We show there no correlation between amount of expressed on targets and susceptibility these lysis or binding cold competition assays. second receptor-positive transformants targets. These were derived from L transfected DNA selected presence Results that, contrast system, expression ability competitively inhibit K562 However, because inhibition not complete, other cell surface antigens probably play role NK-target interactions.