The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population.
作者： Xiaoyan Zhou , Pengli Wang , Hui Zhao
关键词: SNP 、 Genotyping 、 AURKA Gene 、 Biology 、 Single-nucleotide polymorphism 、 Genotype 、 Polymorphism (computer science) 、 Allele 、 Cancer research 、 Aurora Kinase A
摘要: Abstract The Aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastric cancer (GC). overexpression of AURKA promotes inflammation tumorigenesis GC. We performed co-expression analysis to identify genes associated with speculated its function through the COXPRESdb STRING databases. also conducted a hospital-based case-control study involving 385 GC cases 470 controls Chinese population evaluate role rs2273535 polymorphism risk Genotyping was using custom-by-design 48-Plex single nucleotide (SNP) Scan™ Kit. Co-expression indicated that may be poor prognosis In addition, TT genotypes increased by 72% compared AA genotypes. This significant correlation observed allelic dominant models. stratified suggested TT+AT showed positive among female, age < 55 years group nonsmokers conclusion, plays an important development Larger studies more diverse ethnic populations are needed confirm these results.
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sci-hub.se 参考文章(21)
Muhammad Daniyal, Saeed Ahmad, Mukhtiar Ahmad, Hafiz Muhammad Asif, Muhammad Akram, Saif Ur Rehman, Sabira Sultana, Risk Factors and Epidemiology of Gastric Cancer in Pakistan. Asian Pacific Journal of Cancer Prevention. ,vol. 16, pp. 4821- 4824 ,(2015) , 10.7314/APJCP.2015.16.12.4821
Yongming Dai, Yunlian Tang, Fei He, Yang Zhang, Ailan Cheng, Runliang Gan, Yimou Wu, Screening and functional analysis of differentially expressed genes in EBV-transformed lymphoblasts Virology Journal. ,vol. 9, pp. 77- 77 ,(2012) , 10.1186/1743-422X-9-77
Hideo Shigeishi, Naohide Oue, Hiroki Kuniyasu, Atsuko Wakikawa, Hiroshi Yokozaki, Takenori Ishikawa, Wataru Yasui, Expression of Bub1 Gene Correlates with Tumor Proliferating Activity in Human Gastric Carcinomas Pathobiology. ,vol. 69, pp. 24- 29 ,(2001) , 10.1159/000048754
Maria D. Begnami, José Humberto T.G. Fregnani, Suely Nonogaki, Fernando A. Soares, Evaluation of cell cycle protein expression in gastric cancer: cyclin B1 expression and its prognostic implication. Human Pathology. ,vol. 41, pp. 1120- 1127 ,(2010) , 10.1016/J.HUMPATH.2010.01.007
Vikas Sehdev, Ahmed Katsha, Janet Arras, Dunfa Peng, Mohammed Soutto, Jeffrey Ecsedy, Alexander Zaika, Abbes Belkhiri, Wael El-Rifai, HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer Clinical Cancer Research. ,vol. 20, pp. 76- 86 ,(2014) , 10.1158/1078-0432.CCR-13-1187
Petra Hudler, Genetic aspects of gastric cancer instability. The Scientific World Journal. ,vol. 2012, pp. 761909- 761909 ,(2012) , 10.1100/2012/761909
Takeshi Obayashi, Yasunobu Okamura, Satoshi Ito, Shu Tadaka, Ikuko N. Motoike, Kengo Kinoshita, COXPRESdb: a database of comparative gene coexpression networks of eleven species for mammals Nucleic Acids Research. ,vol. 41, pp. 1014- 1020 ,(2012) , 10.1093/NAR/GKS1014
Louise M. Judd, Treve R. Menheniott, Hui Ling, Cameron B. Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S. Giraud, Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo PLoS ONE. ,vol. 9, pp. e95993- ,(2014) , 10.1371/JOURNAL.PONE.0095993
Ahmed Katsha, Mohammed Soutto, Vikas Sehdev, Dunfa Peng, M. Kay Washington, M. Blanca Piazuelo, Mohammed N. Tantawy, H. Charles Manning, Pengcheng Lu, Yu Shyr, Jeffrey Ecsedy, Abbes Belkhiri, Wael El–Rifai, Aurora Kinase A Promotes Inflammation and Tumorigenesis in Mice and Human Gastric Neoplasia Gastroenterology. ,vol. 145, pp. 1312- 1322 ,(2013) , 10.1053/J.GASTRO.2013.08.050
Chisato Hamashima, Current issues and future perspectives of gastric cancer screening World Journal of Gastroenterology. ,vol. 20, pp. 13767- 13774 ,(2014) , 10.3748/WJG.V20.I38.13767