AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children.

摘要: Wilms tumor is the most common type of renal malignancy in children. Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) AURKA gene could predispose to several human malignancies. We recruited 145 cases and 531 cancer-free controls investigate whether variants modify susceptibility. Three SNPs (rs1047972 C>T, rs2273535 T>A, rs8173 G>C) were genotyped by Taqman methodology. Odds ratios (ORs) 95% confidence intervals (CIs) used assess strength association between risk. found only G>C polymorphism was significantly associated with risk (GC vs. GG: adjusted OR (AOR) = 0.50, CI = 0.35–0.73, ; GC/CC AOR = 0.60, CI = 0.42–0.88, ). Stratification analysis revealed genotypes among children aged >18 months (AOR = 0.56, CI = 0.34–0.93, ), male (AOR = 0.54, CI = 0.33–0.90, clinical stage III + IV diseases CI = 0.35–0.90, Haplotype indicated CAG haplotype increased In conclusion, our findings decreased Chinese