Editorial Comment—Prime Time for Proactive Blood Glucose Control?

作者: Risto O. Roine , Perttu J. Lindsberg

DOI: 10.1161/STR.35.11.2498

关键词: InsulinSurgeryTherapeutic effectCardiologyInternal medicineMagnetic resonance imagingLesionGlucose controlIschemiaMedicineInfarctionExperimental research

摘要: There is overwhelming evidence that hyperglycemia detrimental in cerebral ischemia, not only from experimental research but also an increasing number of clinical studies.1,2⇓ Elevated admission glucose levels are associated with increased mortality and worse functional outcome ischemic stroke.3,4⇓ In human magnetic resonance imaging studies, tissue at risk will progress to infarction the presence high blood level, diffusion-weighted lesion grow even recanalized patients receiving thrombolytic therapy.5–7⇓⇓ The mechanisms hyperglycemic cellular injury have been largely clarified.8 Although damage made by reduced lowering therapeutic effect rapidly acting insulin still remains be proven trials.8 This article complements original observation published last year same group: deleterious …

参考文章(16)
Greet Van den Berghe, Pieter Wouters, Frank Weekers, Charles Verwaest, Frans Bruyninckx, Miet Schetz, Dirk Vlasselaers, Patrick Ferdinande, Peter Lauwers, Roger Bouillon, Intensive Insulin Therapy in Critically Ill Patients The New England Journal of Medicine. ,vol. 345, pp. 1359- 1367 ,(2001) , 10.1056/NEJMOA011300
Mark W. Parsons, P. Alan Barber, Jonathon Chalk, David G. Darby, Stephen Rose, Patricia M. Desmond, Richard P. Gerraty, Brian M. Tress, Peter M. Wright, Geoffrey A. Donnan, Stephen M. Davis, Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Annals of Neurology. ,vol. 51, pp. 28- 37 ,(2002) , 10.1002/ANA.10067
W. A. Pulsinelli, S. Waldman, D. Rawlinson, F. Plum, Moderate hyperglycemia augments ischemic brain damage A neuropathologic study in the rat Neurology. ,vol. 32, pp. 1239- 1239 ,(1982) , 10.1212/WNL.32.11.1239
Perttu J. Lindsberg, Risto O. Roine, Hyperglycemia in Acute Stroke Stroke. ,vol. 35, pp. 363- 364 ,(2004) , 10.1161/01.STR.0000115297.92132.84
J. Woo, C. W. K. Lam, R. Kay, A. H. Y. Wong, R. Teoh, M. G. Nicholls, The Influence of Hyperglycemia and Diabetes Mellitus on Immediate and 3-Month Morbidity and Mortality After Acute Stroke JAMA Neurology. ,vol. 47, pp. 1174- 1177 ,(1990) , 10.1001/ARCHNEUR.1990.00530110028011
T. Els, J. Klisch, M. Orszagh, A. Hetzel, J. Schulte-Mönting, M. Schumacher, C.H. Lücking, Hyperglycemia in Patients with Focal Cerebral Ischemia after Intravenous Thrombolysis: Influence on Clinical Outcome and Infarct Size Cerebrovascular Diseases. ,vol. 13, pp. 89- 94 ,(2002) , 10.1159/000047756
Mark W. Parsons, P. Alan Barber, Patricia M. Desmond, Tracey A. Baird, David G. Darby, Graham Byrnes, Brian M. Tress, Stephen M. Davis, Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study Annals of Neurology. ,vol. 52, pp. 20- 28 ,(2002) , 10.1002/ANA.10241
Richard Leigh, Osama O. Zaidat, Muhammad F. Suri, Gwendolyn Lynch, Sophia Sundararajan, Jeffrey L. Sunshine, Robert Tarr, Warren Selman, Dennis M.D. Landis, Jose I. Suarez, Predictors of Hyperacute Clinical Worsening in Ischemic Stroke Patients Receiving Thrombolytic Therapy Stroke. ,vol. 35, pp. 1903- 1907 ,(2004) , 10.1161/01.STR.0000132571.77987.4C
José Alvarez-Sabín, Carlos A. Molina, Joan Montaner, Juan F. Arenillas, Rafael Huertas, Marc Ribo, Agusti Codina, Manuel Quintana, Effects of Admission Hyperglycemia on Stroke Outcome in Reperfused Tissue Plasminogen Activator–Treated Patients Stroke. ,vol. 34, pp. 1235- 1240 ,(2003) , 10.1161/01.STR.0000068406.30514.31
A. Bruno, S. R. Levine, M. R. Frankel, T. G. Brott, Y. Lin, B. C. Tilley, P. D. Lyden, J. P. Broderick, T. G. Kwiatkowski, S. E. Fineberg, Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology. ,vol. 59, pp. 669- 674 ,(2002) , 10.1212/WNL.59.5.669