Predictors of Immunological Failure of Antiretroviral Therapy among HIV Infected Patients in Ethiopia: A Matched Case-Control Study

摘要: Background In resource constrained settings, immunological assessment through CD4 count is used to assess response first line Highly Active Antiretroviral Therapy (HAART). In this study, we aim investigate factors associated with treatment failure. Methods A matched case-control study design was used. Cases were subjects who already experienced failure and controls those without after an exactly or approximately equivalent duration of cases. Data analyzed using SPSS v16.0. Conditional logistic regression carried out. Results total 134 cases included in the study. At baseline, mean age ±1 SD 37.5±9.7 years whereas it 36.9±9.2 among controls. The median baseline counts 121.0 cells/µl (IQR: 47–183 cells/µl) 122.0 80.0–189.8 cells/µl), respectively. rate cells increase comparable for two groups six months commencing HAART (P = 0.442). However, significantly different next 6 period (M6 M12). increment 8.8 0.5, 14.6) 1.8 8.8, 11.3) cells/µl/month cases, respectively (Mann-Whitney U test, P 0.003). conditional regressions grouped 0.028), old group higher educational status (P<0.001) significant predictors failure. Conclusion Subjects have optimal recovery HAART, but relative non-failing declines at a later period, notably between 12 months. Low count, failure.