Barriers for HIV Cure: The Latent Reservoir.

摘要: Thirty-five years after the identification of HIV-1 as causative agent AIDS, we are still in search vaccines and treatments to eradicate this devastating infectious disease. Progress has been made understanding molecular pathogenesis infection, which crucial for development current therapy regimens. However, despite their efficacy at limiting active viral replication, these drugs unable purge latent reservoir: a pool cells that harbor transcriptionally inactive, but replication-competent proviruses, represent main barrier from affected individuals. In review, discuss advances field have allowed better latency, including diverse cell types constitute reservoir, factors influencing tools study well prospective therapeutic approaches target latently infected cells, so functional cure HIV/AIDS can become reality.