The Mre11 Complex Influences DNA Repair, Synapsis, and Crossing Over in Murine Meiosis
作者： Sheila M. Cherry , Carrie A. Adelman , Jan W. Theunissen , Terry J. Hassold , Patricia A. Hunt
DOI: 10.1016/J.CUB.2006.12.048
关键词: Homologous chromosome 、 Meiosis 、 Synapsis 、 Mre11 complex 、 Prophase 、 Chiasma 、 Genetics 、 Chromosomal crossover 、 Synaptonemal complex 、 Biology
摘要: Summary The Mre11 complex (consisting of MRE11, RAD50, and NBS1/Xrs2) is required for double-strand break (DSB) formation, processing, checkpoint signaling during meiotic cell division in S. cerevisiae [1–8]. Whereas studies mutants pombe A. thaliana indicate that the has other essential roles [9–11], relatively little known regarding functions downstream formation processing or its role meiosis higher eukaryotes. We analyzed events mice harboring hypomorphic Nbs1 mutations which, unlike null mutants, support viability [12–16]. Our revealed defects temporal progression prophase, incomplete aberrant synapsis homologous chromosomes, persistence strand exchange proteins, alterations in both frequency placement MLH1 foci, a marker crossovers. A unique sex-dependent effect on foci chiasmata numbers was observed: males exhibited an increase females a decrease recombination levels. Thus, our findings implicate DNA repair mammals may contribute to establishment normal sex-specific differences meiosis.
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