Novel males' capacity to disrupt early pregnancy in mice (Mus musculus) is attenuated via a chronic reduction of males' urinary 17β-estradiol

摘要: Summary Mature male mice of proven fertility were administered chronic oral doses anastrozole, a potent aromatase inhibitor, and also given low-phytoestrogen diet. Urine was taken non-invasively from such males untreated control assayed for 17β-estradiol testosterone via ELISA procedures. After 8 weeks drug or vehicle administration, urinary declined to significantly lower levels in anastrozole-treated than non-treated males, whereas comparable the two groups. Inseminated females exposed drug-treated, vehicle-treated, no during days 1–6 gestation, around intrauterine implantation fertilized ova. Females vehicle-treated produced fewer litters did those kept isolation. more males. These data support notion that excretions estrogens may part mediate novel-male-induced pregnancy disruptions, although other influences aromatization on behaviour metabolism remain possibilities.