Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial

摘要: Objectives We sought to evaluate the effect of aspirin plus clopidogrel versus alone on saphenous vein graft occlusion at 3 months after coronary artery bypass grafting (CABG). Background Prevalence is high CABG. Aggressive antiplatelet therapy expected improve early post-operative patency. Methods From December 2007 through 2008, 249 consecutive patients undergoing elective CABG Fuwai Hospital were randomly assigned 2 groups: 124 received (100 mg) (75 daily (AC group), and 125 (A group). Antiplatelet therapies initiated when chest tube drainage was ≤30 cc/h for h. All participants invited clinical follow-up 64-slice multislice computed tomography angiography (MSCTA) analysis post-operatively. Generalized estimating equations used determine predictors Results One participant, from group A, died before 3-month follow-up. Of remaining 248 patients, 224 (90.3%) underwent MSCTA. Participants had similar pre-operative intraoperative characteristics baseline. No significant differences observed in transit-time flow measurement findings or major adverse cardiac-related events. Three-month MSCTA revealed that patency 91.6% (219 239) AC 85.7% (198 231) A (p = 0.043). In multivariate analysis, combined independently increased venous 0.045). Conclusions Aspirin more effective than short term CABG, but further, long-term study needed. (The Clopidogrel After Surgery Coronary Artery Disease; NCT00776477 )