Early Potent Antithrombotic Effect With Combined Aspirin and a Loading Dose of Clopidogrel on Experimental Arterial Thrombogenesis in Humans
作者： Yves Cadroy , Jean-Pierre Bossavy , Claire Thalamas , Luc Sagnard , Kjell Sakariassen
DOI: 10.1161/01.CIR.101.24.2823
关键词: Platelet 、 Thrombosis 、 Anesthesia 、 Antithrombotic 、 Aspirin 、 Crossover study 、 Medicine 、 Perfusion 、 Loading dose 、 Clopidogrel
摘要: Background—We conducted a double-blind, randomized, crossover study to assess the antithrombotic effects of combination aspirin (acetylsalicylic acid, ASA) and clopidogrel, with or without loading dose, versus ASA alone in model arterial thrombosis humans. Methods Results—Eighteen male volunteers received following 3 regimens for 10 days separated by 1-month period: (1) 325 mg daily, (2) ASA+75 clopidogrel (3) daily+300-mg dose on day 1 +75 per 2 10. The effect was measured 1.5, 6, 24 hours after drug intake 6 Arterial thrombus formation induced ex vivo exposing collagen-coated coverslip parallel-plate perfusion chamber native blood minutes at an wall shear rate. Without clopidogrel+ASA developed within first intake. It superior tha...
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