HER2 oncogene amplification in extramammary Paget's disease
作者： M Tanskanen , T Jahkola , S Asko-Seljavaara , J Jalkanen , J Isola
DOI: 10.1046/J.1365-2559.2003.01648.X
关键词: Gene duplication 、 Immunostaining 、 Carcinogenesis 、 Fluorescence in situ hybridization 、 Immunohistochemistry 、 Biology 、 Pathology 、 Adenocarcinoma 、 Extramammary Paget's disease 、 Immunotherapy
摘要: Aims: To study HER2 oncogene amplification and over-expression in skin samples of 23 patients with extramammary Paget's disease (EMP). EMP is a rare intra-epidermal adenocarcinoma, which has been reported to over-express the oncoprotein. Methods results: HER2 gene amplification, detected by chromogenic in-situ hybridization, was found 43% (10/23) lesions. protein (3+ immunostaining intensity) 12 tumours (52%), including all 10 amplification. Two showed low-level (2+) immunostaining. Mammary lesions, were used as controls, cases studied. Conclusions: These results indicate that HER-2 common due exclusively They open up possibility HER2-targetted immunotherapy for HER2+ disease.
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