Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.

摘要: In humans, nonaqueous solvents are administered intravascularly in two kinds of situations. They have been used subcutaneous or intramuscular pharmaceutical formulations to dissolve water-insoluble drugs. The need for these vehicles had increased recent years, since the drug development process has yielded many poorly water-soluble use water-miscible therefore one approaches administering products as reference solutions useful formulation bioequivalence studies. intravascular organic also gained importance owing a new approach treatment cerebral malformations using precipitating polymers dissolved solvents. At present, solvent most commonly liquid embolics solubilize is dimethyl sulfoxide, which exhibits some local and hemodynamic toxicities. order find new, less toxic intravenous intra-arterial routes embolic materials, 13 currently (diluted with water) applications, were evaluated this study. Their hemolytic activity morphological changes induced when mixed blood (1:99, 5:95, 10:90 solvent:blood) estimated vitro. From data, selected could be subdivided into four groups depending on their activity: very highly (ethyl lactate, sulfoxide), (polyethylene glycol 200, acetone), moderately (tetrahydrofurfuryl alcohol, N-methyl-2-pyrrolidone, glycerol formal, ethanol, Solketal, glycofurol) low (propylene glycol, isosorbide, diglyme).