Histamine modulates cellular events involved in tumour invasiveness in pancreatic carcinoma cells.
作者： G. Cricco , M. Núñez , V. Medina , G. Garbarino , N. Mohamad
DOI: 10.1007/S00011-005-0054-9
关键词: Extracellular 、 Growth factor 、 Adenocarcinoma 、 Cancer research 、 Matrix metalloproteinase 、 Cell culture 、 Cell adhesion 、 Histamine receptor 、 Histamine 、 Oncology 、 Chemistry 、 Internal medicine
摘要: Progression of epithelial tumours to metastatic stage is characterized by increased motility, decrease in cellular adhesion, high expression and activation metalloproteases (MMPs) angiogenic capability. Pancreatic adenocarcinoma highly aggressive malignant tumour which rapidly progresses. Previously we have reported human pancreatic cell line PANC-1 overexpresses H1 H2 histamine receptors. These cells synthesize secrete (HA) the extracellular medium where it acts as a growth factor modulating proliferation via receptors [1, 2]. Thus HA on adhesion migration plus role MMPs invasive potential this was studied.
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