Vascular relaxation mediated by hydroxylamines and oximes: Their conversion to nitrites and mechanism of endothelium dependent vascular relaxation
作者： George Thomas , Peter W. Ramwell
DOI: 10.1016/0006-291X(89)91542-8
关键词: Oxime 、 Relaxation (physics) 、 Mechanism of action 、 Vasodilation 、 Hydroxylamine 、 Chemistry 、 Endothelium 、 Methylene blue 、 Stereochemistry 、 Endothelium-derived relaxing factor 、 Medicinal chemistry 、 Biophysics 、 Cell biology 、 Biochemistry 、 Molecular biology
摘要: Hydroxylamines (RNHOH) and oximes (RNOH) relax rat aortic rings independent of the presence endothelium. The relaxation is inhibited by methylene blue, an inhibitor soluble guanylate cyclase hemoglobin, endothelium dependent relaxing factor (EDRF). Both hydroxylamines generate NONO2− ions on treatment with iodine in glacial acetic acid. However, there no correlation between formation. Compared to hydroxylamines, are less potent agents not efficiently converted ions. We suggest that associated a hydroxylamine like compound directly related NO.
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