Effect of Nα-benzoyl-L-arginine ethyl ester on coronary perfusion pressure in isolated guinea pig heart
作者： George Thomas , Michel Farhat , Adam K. Myers , Peter W. Ramwell
DOI: 10.1016/0014-2999(90)90484-N
关键词: Anesthesia 、 Guinea pig heart 、 Coronary perfusion pressure 、 In vitro 、 Endothelium-derived relaxing factor 、 Circulatory system 、 Coronary vessel 、 Benzoyl-L-arginine ethyl ester 、 Medicine 、 Guinea pig 、 Pharmacology
摘要: Abstract Nα-Benzoyl-L-arginine ethyl ester (BAEE) when compared to L-arginine significantly decreased coronary perfusion pressure of isolated guinea pig heart in a dose dependent and reproducible manner. This effect BAEE was antagonized by haemoglobin N-monomethyl L-arginine, both inhibitors endothelium relaxation. These results support the notion that mechanism relaxation elicited is due generation relaxing factor (EDRF) like agents.
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