Cell therapy in Parkinson's disease - stop or go?

作者: Stephen B. Dunnett , Anders Björklund , Olle Lindvall

DOI: 10.1038/35072572

关键词: Parkinson's diseaseEmbryonic TissueBioinformaticsKey issuesDiseaseCell replacementCell therapyMedicine

摘要: The results of the first double-blind placebo-controlled trial using grafts embryonic tissue to treat Parkinson's disease have aroused widespread interest and debate about future cell replacement therapies. What are key issues that need be resolved directions in which this technology is likely develop?

参考文章(55)
Olle Lindvall, Peter Hagell, None, Clinical observations after neural transplantation in Parkinson's disease Progress in Brain Research. ,vol. 127, pp. 299- 320 ,(2000) , 10.1016/S0079-6123(00)27014-3
Outbreaks of enterovirus 71 infection. The New England Journal of Medicine. ,vol. 342, pp. 355- 356 ,(2000) , 10.1056/NEJM200002033420513
S. B. Dunnett, Anders Björklund, Functional neural transplantation Raven Press. ,(1994)
Hansjörg Sauer, Patrik Brundin, Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts. Restorative Neurology and Neuroscience. ,vol. 2, pp. 123- 135 ,(1991) , 10.3233/RNN-1991-2302
Erik-Olof Backlund, Per-Ola Granberg, Bertil Hamberger, Evert Knutsson, Anders Mårtensson, Göran Sedvall, Åke Seiger, Lars Olson, Transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials. Journal of Neurosurgery. ,vol. 62, pp. 169- 173 ,(1985) , 10.3171/JNS.1985.62.2.0169
Patrik Brundin, Jenny Karlsson, Mia Emgård, Gabriele S. Kaminski Schierle, Oskar Hansson, Åsa Petersén, Roger F. Castilho, Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplantation. ,vol. 9, pp. 179- 195 ,(2000) , 10.1177/096368970000900205
Paola Piccini, David J. Brooks, Anders Björklund, Roger N. Gunn, Paul M. Grasby, Ornella Rimoldi, Patrik Brundin, Peter Hagell, Stig Rehncrona, Håkan Widner, Olle Lindvall, Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient Nature Neuroscience. ,vol. 2, pp. 1137- 1140 ,(1999) , 10.1038/16060
Christian Winkler, Deniz Kirik, Anders Björklund, Stephen B. Dunnett, Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement. Progress in Brain Research. ,vol. 127, pp. 233- 265 ,(2000) , 10.1016/S0079-6123(00)27012-X